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KMID : 0870519980020010029
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Journal of Korean Academy of Addiction Psychiatry
1998 Volume.2 No. 1 p.29 ~ p.35
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Change of Regional Cerebral Blood Flow in Alcoholics
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Lee Chung-Tai
Sohn Hyung-Sun
Sung Yang-Sook
Yang Mun-Jung
Chae Jeong-Ho
Bahk Won-Myong
Kim Kwang-Soo
Lew Tae-Yul
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Abstract
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The purpose of this study was to investigate the effect of chronic alcohol intake to regional cerebral blood flow in the patients with alcohol dependence by single photon emission computerized tomography (SPECT). The subjects were
detoxified alcoholic inpatients (n＝10) diagnosed as alcohol dependence by DSM-IV criteria and control group (n＝8).
The regions of interest (ROIs) were drawn in frontal lobe (3 ROIs), temporal lobe (3 ROIs), parietal lobe (3 ROIs),
occipital lobe (1 ROI), and thalamus (1 ROI). We compared data from chronic alcoholic patients to those from controls
about cerebral asymmetry indices and regional cerebral blood flow (rCBF) indices measured from each ROI. The results
were as follows：1) There were significant differences in asymmetry indices of thalamus with alcoholic patients and
control group (p<0.05). 2) rCBF indices of alcoholic patients were significantly higher than those of control group in left
posterior temporal cortex, right posterior parietal cortex and right thalamus (p<0.05), and tended strongly to be higher
than those of control group in right posterior temporal cortex, left posterior parietal cortex and left superior lateral frontal
cortex. The result of increased rCBF in cerebral cortex and thalamus of detoxified inpatients with alcohol dependence
suggested that there may exist a significant association between alcohol dependence and frontothalamic circuitry as brain
reward system. In comparison of rCBF in both hemispheres, rCBF in right thalamus was observed to increase, which is
possibly associated with impulsivity and change of affective status. Further research on the change of rCBF according to the duration after alcohol withdrawal is warranted.
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KEYWORD
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Alcohol dependence, Single photon emission computerized tomography (SPECT), Regional cerebral blood flow, Brain reward system
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